Synthesis of antibacterial TiO2/PLGA composite biofilms

TiO2/PLGA composite biofilms for artificial dressing applications have been developed. The antibacterial activity of the fabricated TiO2/PLGA composite was measured against Staphylococcus aureus and Escherichia coli. The feasibility of the biomaterial on wound healing in vitro was evaluated by seeding human keratinocytes (HaCaT), fibroblasts (L929), and bovine carotid artery endothelial cells (BECs) on the TiO2/PLGA composite biofilms. Experimental results indicate that TiO2/PLGA composite biofilms containing 10% of TiO2 nanoparticles could be more suitable on nonendothelial tissues, such as the epidermis.174