A novel polyethylene glycol mediated lipid nanoemulsion as drug delivery carrier for paclitaxel

The novel polyethylene glycol 400 mediated two-vial formulation of paclitaxel (PTX)-loaded lipid nanoemulsion (TPLE) was successfully developed, which displayed distinctly faster release of PTX and a greater proportion of PTX in phospholipids layer and could significantly reduce extraction of the reticuloendothelial system (RES) organs and enhance tumor-uptake and in vivo antitumor efficacy compared to conventional PTX-loaded lipid nanoemulsion (CPLE). Moreover, TPLE could not cause haematolysis and intravenous irritation response yet, and exhibited the same cytotoxicity against HeLa cells as Taxol®, and its LD50 was 2.7-fold higher than that of Taxol®, indicating its good safety and druggability.78