Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

Cellular binding and uptake of nanoparticles by alveolar macrophages was increased for nanoparticles with adsorbed SP-A, whereas adsorption of BSA led to a significant decrease. These findings emphasize that the protein coating formed around a nanoparticle and thus the biological behavior varies with the respective physiological compartment.259