Temperature and pH dual-responsive cross-linked polymeric nanocapsules with controllable structures via surface-initiated atom transfer radical polymerization from templates

The novel drug carrier, controllable-structured intelligent nanocapsules with the temperature-responsive crosslinked polymer shells and the pH- responsive polymer brushes in their inner walls have been designed and fabricated by using the “polymerization from template” strategy via the surface-initiated atom transfer radical polymerization (SI-ATRP) technique from the silica nanoparticles as sacrificial templates.124