Formation of nanoparticles of a hydrophilic drug using supercritical carbon dioxide and microencapsulation for sustained release

Nanoparticles of dexamethasone phosphate can be produced with the SAS-EM technique. When microencapsulated, these particles can provide sustained drug release without initial burst release. Because the complete process is anhydrous, it can be easily extended to produce sustained release formulations of other hydrophilic drugs.