کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10441464 | 914173 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The mediating role of novelty seeking in the association between the type 4 dopamine receptor gene polymorphism and cigarette-smoking behavior
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The mediating role of novelty seeking in the association between the type 4 dopamine receptor gene polymorphism and cigarette-smoking behavior The mediating role of novelty seeking in the association between the type 4 dopamine receptor gene polymorphism and cigarette-smoking behavior](/preview/png/10441464.png)
چکیده انگلیسی
We examined the relationship between type 4 dopamine receptor gene and cigarette-smoking behavior and the mediating role of the temperamental dimension novelty seeking (NS). Participants were 150 smoking and non-smoking high and low NS scorers from a randomized population-based sample of 20-35 year old men and women. We genotyped the participants for a 48 base-pair repeat polymorphism in the DRD4 gene. Novelty seeking was assessed by the Temperament and Character Inventory. The two- and five-repeat alleles were significantly more common in the group of current smokers than others (odds ratio 2.53, 95% CI 1.06-6.01). After controlling for the effect of novelty seeking on smoking behavior, the relationship dropped substantially, being no longer statistically significant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Personality and Individual Differences - Volume 38, Issue 3, February 2005, Pages 639-645
Journal: Personality and Individual Differences - Volume 38, Issue 3, February 2005, Pages 639-645
نویسندگان
Marko Elovainio, Mika Kivimäki, Jorma Viikari, Jesper Ekelund, Liisa Keltikangas-Järvinen,