کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10454216 920742 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Norepinephrine and epinephrine responses to physiological and pharmacological stimulation in chronic fatigue syndrome
ترجمه فارسی عنوان
پاسخ نوراپی نفرین و اپی نفرین به تحریک فیزیولوژیکی و دارویی در سندرم خستگی مزمن
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Chronic fatigue syndrome (CFS) is characterized by fatigue lasting 6 months or longer. CFS has been associated with a disturbed (re-)activity of the autonomic nervous system. However, the sympathetic adrenomedulla (SAM) remains under-examined in CFS. To investigate SAM reactivity, we implemented a submaximal cycle ergometry (ERGO) and a pharmacological test (Insulin Tolerance Test, ITT) in 21 CFS patients and 20 age-, sex-, and BMI-matched controls. Plasma norepinephrine and epinephrine were collected once before and twice after the tests (+10/+20, and +30 min). Lower baseline levels and attenuated responses of epinephrine to the ERGO were found in CFS patients compared to controls, while the groups did not differ in their responses to the ITT. To conclude, we found evidence of altered sympathetic-neural and SAM reactivity in CFS. Exercise stress revealed a subtle catecholaminergic hyporeactivity in CFS patients. It is conceivable that inadequate catecholaminergic responses to physical exertion might contribute to CFS symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychology - Volume 94, Issue 1, September 2013, Pages 160-166
نویسندگان
, , , , ,