Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley

► Opioid and related hedonic hotspots in accumbens and ventral pallidum amplify food 'liking'. ► Larger striatal networks, including amygdala and neostriatum, generate 'wanting'. ► Accumbens shell amino acid and dopamine mechanisms of 'wanting' surprisingly also generate fear. ► Mesocorticolimbic activity transforms the value of previously learned memories, without new learning.