From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction

► Kratom/Ketum is a plant preparation with the psychoactive compound mitragynine. ► Kratom is used in Southeast Asia but currently spreading world wide. ► Mechanisms of action involve opioid receptors and monoaminergic systems. ► There are potential medical applications for mitragynine analogues. ► There is evidence for an addiction potential of Kratom and mitragynine.