Update: Studies of prepulse inhibition of startle, with particular relevance to the pathophysiology or treatment of Tourette Syndrome

► We review the cross-species utility of prepulse inhibtion (PPI) as an operational measure of sensorimotor gating. ► PPI deficits in Tourette Syndrome (TS) and in other neurodevelopmental brain disorders are discussed. ► The neurobiological regulation of PPI by forebrain circuitry implicated in the pathophysiology of TS is described. ► A conceptual linkage is noted between deficient sensorimotor gating and intrusive sensory phenomena now recognized as a core feature of TS. ► An update of recent findings relevant to the relationship of PPI to TS is provided.