Brain connectivity during resting state and subsequent working memory task predicts behavioural performance

► We used rest-fMRI followed by n-back task-fMRI to study human brain connectivity. ► The working memory network (WMN) and the default mode network (DMN) were identified. ► DMN and WMN had the maximal intrinsic connectivity at the highest cognitive load. ► The negative correlation between networks predicted performance during the task. ► Connectivity of posterior attentional node of the DMN at rest predicted performance.