A specific role for septohippocampal acetylcholine in memory?

► We review effects of lesion/pharmacological disruption to the cholinergic system. ► We review a model of the role of septohippocampal acetylcholine in memory. ► We review recent behavioural loss-of-function and electrophysiological data. ► We use the model to explain deficits after septohippocampal cholinergic disruption.