Does possession of apolipoprotein E ɛ4 benefit cognitive function in healthy young adults?

► Does APOE ɛ4 exhibit “antagonistic pleiotropy”? ► Are ɛ4-related cognitive deficits in old age offset by benefits in young adulthood? ► The study, the largest to examine these questions (n = 5445), indicates “No”. ► Due to the sample size, unlikely the findings are subject to a Type II error. ► Neuropathology may play a key role in ɛ4-cognitive relations in both young and old.