Serotonergic modulation in executive functioning: Linking genetic variations to working memory performance

► Genetic variations of the 5-HT pathway (5-HTTLPR, MAOA) impact on working memory. ► 5-HT modulation is evidenced by RT, error rate and ERP associations (via n-back). ► Epistatic effects of 5-HT polymorphisms with NE gene variation (NET −3081) emerged. ► 5-HT genes may impact on inhibitory control as implicated in working memory. ► Results suggest a crucial role of 5-HT neuromodulation in executive functioning.