On the role of fronto-striatal neural synchronization processes for response inhibition-Evidence from ERP phase-synchronization analyses in pre-manifest Huntington's disease gene mutation carriers

► Habitual response inhibition barely requires reliable neural synchronization. ► Deficits in pre-manifest HD occur only in non-habitual response inhibition. ► Dysfunctions in phase-synchronization processes underlie these deficits. ► Genetic disease load determines the degree of phase-locking dysfunctions. ► Phase-synchronization properties predict pre-manifest disease progression.