کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10510231 | 949482 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dopamine receptor regulation of ethanol intake and extracellular dopamine levels in the ventral pallidum of alcohol preferring (P) rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Sufficient evidence exists for the inclusion of the ventral pallidum (VP) into the category of a dopaminoceptive brain region. The effects of inhibiting dopamine D1- or D2-like receptors in the VP on (a) ethanol intake and (b) extracellular levels of dopamine, were investigated in the alcohol-preferring (P) rat. The D1-like antagonist, SCH-23390, and the D2-like antagonist, sulpiride (0.25-2 μg/0.5 μl) were bilaterally injected into the VP and ethanol (15%, v/v) intake was assessed in a 1 h limited access paradigm. The results indicate that microinjections of sulpiride significantly increased ethanol consumption (65% increase at the 2.0 μg dose). Whereas the D1 antagonists SCH-23390 tended to decrease ethanol intake, the effect was not statistically significant. In a separate group of rats, reverse microdialysis of sulpiride and SCH-23390 (10-200 μM) were conducted in the VP of P rats. Local perfusion of only the 200 μM sulpiride dose significantly increased the extracellular levels of dopamine (maximal increase: 250% of baseline). On the other hand, local perfusion of SCH-23390 (10-200 μM) dose dependently increased the extracellular levels of dopamine 180-640% of baseline. Overall, the results of this study suggest that (a) tonic activation of D2 postsynaptic receptors in VP imposes a limit on ethanol intake in the P rat; (b) there are few D2 autoreceptors functioning in the VP; (c) there is tonic D1-like receptor mediated inhibitory feedback regulation of VP-dopamine release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 77, Issue 3, 7 March 2005, Pages 293-301
Journal: Drug and Alcohol Dependence - Volume 77, Issue 3, 7 March 2005, Pages 293-301
نویسندگان
Roberto I. Melendez, Zachary A. Rodd, William J. McBride, James M. Murphy,