Rhubarb inhibits hepatocellular carcinoma cell metastasis via GSK-3-β activation to enhance protein degradation and attenuate nuclear translocation of β-catenin

► Rhubarb can downregulate Wnt signalling in liver cancer cells. ► Rhubarb decreases phosphorylation of GSK-3β and increases its activity. ► Rhubarb reduced β-catenin, cyclin D, Tbx3 and c-Myc. ► Rhubarb attenuated the expression of MMP9 and contactin-1 metastatic factors.