Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation

► Wild bitter melon extract suppresses Propionibacterium acnes-induced inflammation. ► Saponifiable and nonsaponifiable fractions of extract reduced pro-inflammatory cytokines in P. acnes-stimulated THP-1 cells. ► The bioactive components of extract possessed PPARα and PPARγ agonistic activities.