Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages

► Lipophilic ester derivatives of EGCG were prepared. ► They inhibited NO and PGE2 production in LPS-stimulated macrophage. ► They down-regulated iNOS and COX-2 gene expression at transcriptional level. ► They may be useful in preventing/treating inflammation and related diseases.