Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages

► The antiangiogenic effects of indole-3-carbinol (I3C) were explored. ► Lipopolysaccharide-activated macrophages stimulate tube formation of endothelial cells, and I3C suppresses such enhancement. ► These effects are associated with increased production of NO, VEGF, IL-6, and MMP. ► Inhibited activations of both macrophages and endothelial cells contribute to the antiangiogenic activity of I3C.