Cyanidin suppresses neoplastic cell transformation by directly targeting phosphatidylinositol 3-kinase

► We compared the anti-carcinogenic effect and mechanisms of cyanidin and C3G. ► Cyanidin suppressed EGF-induced cell transformation more strongly than C3G. ► Cyanidin and C3G showed similar effects against radical scavenging activity. ► Cyanidin, but not C3G, inhibited the EGF-induced Akt/p70S6K signalling pathway. ► Cyanidin suppressed the PI3K activity by binding to PI3K directly.