Alterations in antioxidant enzyme activities and oxidative damage in alcoholic rat tissues: Protective role of Thespesia populnea

► TP-Leaf effects on alcohol toxicity were measured by antioxidant enzyme activities. ► Activity of enzymes was restored significantly after treatment with leaf extract. ► TP-E protects liver and kidney from oxidative damage, confirmed by histopathology. ► AQ-E (leaf) was found to be the most effective, and can be used in herbal medicine. ► TP can be used to cure alcohol related disorders and to enhance antioxidant activity.