Anti-angiogenic effects and mechanisms of zerumin A from Alpinia caerulea

► Ethanol extracts of the fruits of Alpinia caerulea showed antiangiogenic effects. ► Zerumin A from the fruits inhibited vessel formation in zebrafish embryos. ► Zerumin A affected multiple molecular targets of angiogenesis in zebrafish embryos. ► Zerumin A inhibited human umbilical vein endothelial cell proliferation and migration.