Structural characterisation and anti-ageing activity of extracellular polysaccharide from a strain of Lachnum sp.

► We have separated and purified LEPS-1 with the molecular weight of 21670 Da. ► LEPS-1 was a glucan linked by the β-(1 → 3)-d-pyran glycosidic bond. ► LEPS-1 significantly enhanced the antioxidase activity in the body of aged mice. ► LEPS-1 significantly inhibit the formation of lipid peroxidation products and slowed down the aging process. ► LEPS-1 has a strong anti-ageing activity in d-gal-induced senescent mice.