Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats

► An optimised nano-curcumin-loaded PLGA was prepared to enhance bioavailability. ► A conscious and freely-moving rat model was used to examine. ► The oral bioavailability of nano-formulation was about 22-fold enhanced. ► The faecal excretion was decreased approximately 45% for nano-curcumin.