Prediction of the amount and rate of histamine degradation by diamine oxidase (DAO)

► Predicted the rate and amount of histamine degradation by DAO in buffer (model) and tuna soup (real) system. ► In model system salt was not significant to DAO activity and reached optimum histamine degradation within pH 6-6.5. ► The real system showed that the optimum oxidation of histamine using DAO occurred at salt levels 1-3% and pH 6-7.