In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

► Aqueous cinnamon extract lowered fasting blood glucose in diet induced obese mice. ► Cinnamon polyphenol-enriched flour lowered blood glucose in diet induced obese mice. ► Cinnamon polyphenols inhibited hepatic glucose production. ► Cinnamon extract decreased gene expression of glucose-6-phosphatase. ► Cinnamon extract decreased gene expression of phosphoenolpyruvate carboxykinase.