Simultaneous determination of iridoid glycosides, phenethylalcohol glycosides and furfural derivatives in Rehmanniae Radix by high performance liquid chromatography coupled with triple-quadrupole mass spectrometry

► An HPLC-TQ-MS method for holistic quality evaluation of Rehmanniae Radix was developed and validated. ► Three kinds of bioactive components were selected as quantitative markers. ► SIR scan mode was employed for improvement of selectivity and sensitivity. ► Different batches of raw and processed Rehmanniae Radix were compared.