Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology

► An ionic liquid based ultrasonic assisted extraction (ILUAE) has been developed. ► ILUAE combines the advantages of UAE and beneficial properties of ILs. ► ILUAE is becoming one of the attractive and promising extraction techniques. ► It offered shorter extraction time and higher efficiencies than conventional method.