Body weight management effect of burdock (Arctium lappa L.) root is associated with the activation of AMP-activated protein kinase in human HepG2 cells

► Burdock (Arcticum lappa L.) root treatment significantly reduced body weight in rats. ► The AL-2 contained ingredients with the most effective hypolipidemic potential. ► Burdock root suppresses lipid synthesis by activating AMPK. ► Burdock root is expected to be useful for anti-obesity.