Thermodynamic analysis of the thermal stability of sulphonamides in milk using liquid chromatography tandem mass spectrometry detection

► We investigated the kinetics of sulphonamides in milk during heating by LC-MS/MS. ► Sulphonamides show high stability at heat treatments used in dairy processing. ► The existence of thermodynamic compensation was also tested. ► The thermal degradation of sulphonamides exhibits enthalpy-entropy compensation.