Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling

► Phillyrin inhibits high glucose-induced lipid accumulation by suppressing fatty acid synthase (FAS). ► Phillyrin inhibits FAS expression through modulation of SREBP-1c activation. ► Phillyrin promotes AMPKα phosphorylation in human HepG2 hepatocytes. ► Phillyrin-induced activation of AMPK is regulated by LKB1.