Synthesis of quinoline derivatives of tetrahydrocurcumin and zingerone and evaluation of their antioxidant and antibacterial attributes

► Novel quinoline derivatives of THC and zingerone have been synthesised. ► The amino-substituted quinoline derivatives of THC and zingerone showed best RSA. ► Quinoline derivatives of THC and zingerone showed strong antimicrobial activity. ► The molecules may have possible pharmacological applications.