Reduction of lipid accumulation in white adipose tissues by Cassia tora (Leguminosae) seed extract is associated with AMPK activation

► We examined the effect of Cassia seed ethanol extract (CSEE) on the reducing lipid accumulation. ► CSEE decreased the intracellular accumulation of trigycerides in 3T3-L1 adipocytes. ► CSEE attenuated lipid accumulation in white adipose tissue through AMP-activated protein kinase signaling pathway. ► CSEE may have potential use as a therapy for the treatment of obesity and hyperlipidemia.