The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and α-tocopherol

► We studied the presumed cooperation between lycopene, ascorbic acid and α-tocopherol. ► The effect on lipid peroxidation and inflammation was assessed. ► Lipid peroxidation was effectively inhibited by the combinations of compounds. ► Lycopene on its own effectively reduced inflammation. ► The activities of the compounds are complementary at different levels within the inflammation process.