Terpenoids and hexenes from the leaves of Crataegus pinnatifida

► Taking it into consideration that Crataegus pinnatifida is a medicine and food material. ► The leaves of C. pinnatifida was subjected to phytochemical investigation resulting in the isolation of four novel compounds. ► Their chemical structures were elucidated by their physicochemical properties and spectral data. ► Cytotoxicity of the new compounds was assayed against selected human glioma (U87) cell lines. ► To the best of our knowledge, this is the first report of sesquiterpene isolated from this plant.