Taurine protects murine hepatocytes against oxidative stress-induced apoptosis by tert-butyl hydroperoxide via PI3K/Akt and mitochondrial-dependent pathways

► Oxidative stress is considered as a key event in tert-butyl hydroperoxide (TBHP)-induced cytotoxicity. ► TBHP causes mitochondrial dysfunction, loss of cellular respiration and apoptosis. ► Taurine normalises cellular antioxidant machineries disturbed due to TBHP toxicity. ► Taurine exerts protective action via PI3K/Akt by inhibiting NF-κB upregulation. ► Taurine may act as a potential therapeutic agent in TBHP-induced hepatic damage.