Application of cavitation system to accelerate the endogenous enzymatic hydrolysis of baicalin and wogonoside in Radix Scutellariae

► The effect of cavitation system on the hydrolysis efficiency was investigated. ► The novel negative pressure cavitation (NPC) system was applied to accelerate the chemical processes and mass transfer. ► The mass transfer and reaction kinetics control the yield of baicalein in Radix Scutellariae. ► The endogenous-enzymatic hydrolysis with cavitation was proved to be a highly efficient and green-environmently method. ► The transformation ratio of baicalin and wogonoside reached 98.21% and 96.60% at 50 °C for 60 min.