Thermodynamics of the interaction of sweeteners and lactisole with fullerenols as an artificial sweet taste receptor model

► Interaction of lactisole and sweeteners with fullerenols was elucidated. ► Two interaction equilibrium states were found in ITC titration profiles. ►A competitive binding of sweeteners and inhibitor with fullerenols was found. ► The inhibition efficiency of lactisole on a variety of sweeteners was evaluated.