کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10542350 963461 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of Monascus-fermented grain extracts on plasma antioxidant status and tissue levels of ubiquinones and α-tocopherol in hyperlipidemic rats
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Effects of Monascus-fermented grain extracts on plasma antioxidant status and tissue levels of ubiquinones and α-tocopherol in hyperlipidemic rats
چکیده انگلیسی
We investigated the effects of Monascus-fermented mixed grain extracts (MFGEs) enriched with bioactive mevinolins (natural statins) and coenzyme Qs (CoQ9 + CoQ10) on the blood lipids, antioxidant status, and tissue levels of CoQs and α-tocopherol (α-Toc) in hyperlipidemic rats. The oral administration of MFGEs (300 mg/kg body weight per day) for 8 weeks resulted in a significant decrease in blood levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and LDL-C/high-density lipoprotein cholesterol (HDL-C) ratio compared to the control and lovastatin supplement group of a dosage of 20 mg/kg per day (p < 0.05). Furthermore, a significant increase in the ratios of α-Toc/LDL-C and CoQs/LDL-C in plasma and tissues and improvement in plasma antioxidant status as measured by TBARS and TRAP were observed in hypercholesterolemic rats (p < 0.05). Regarding the effects of MFGEs on antioxidant levels of plasma and tissues, there were significant increases in the levels of α-Toc (p < 0.05) and CoQs (p < 0.01) after the 8-week MFGEs treatment. These data indicate that MFGEs supplementation not only decreases blood lipids and lipid peroxidation but also increases levels of antioxidants such as α-Toc and CoQs and may improve plasma antioxidant status as well as a hypolipidemic effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 141, Issue 1, 1 November 2013, Pages 428-435
نویسندگان
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