The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro

► Alzheimer's protein amyloid-β and pro-oxidants elicit neurotoxicity in PC12 cells. ► We compared protective effects of bioactive polyphenols against these stressors. ► (−)-Epigallocatechin-3-gallate and grape skin extract protect against amyloid-β. ► (−)-Epigallocatechin-3-gallate directly inhibits amyloid-β aggregation. ► Bioactive amyloid-β aggregation inhibitors may confer a neuroprotective advantage.