کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10566 691 2007 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Active targeting of brain tumors using nanocarriers
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Active targeting of brain tumors using nanocarriers
چکیده انگلیسی

The delivery of drugs to brain tumors is limited by the presence of the blood–brain barrier (BBB) separating the blood from the cerebral parenchyma. An understanding of the specific mechanisms of the brain capillary endothelium has led to the development of various strategies to enhance the penetration of drugs into the brain tissue. Active targeting is a non-invasive approach, which consists in transporting drugs to target organs using site-specific ligands. Drug-loaded nanocarriers capable of recognizing brain capillary endothelial cells and cerebral tumoral cells have shown promising potential in oncology. Endogenous and chimeric ligands binding to carriers or receptors of the BBB have been directly or indirectly conjugated to nanocarriers. This review indexes the main targeted colloidal systems used for drug delivery to the brain. Their pharmacological behavior and their therapeutic effect are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 28, Issue 33, November 2007, Pages 4947–4967
نویسندگان
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