One-pot synthesis of difluoromethyl-containing dihydropyrimidinones catalyzed by Yb(PFO)3 under solvent and dehydrating agent free conditions

▶ Synthesis of difluoromethyl-containing dihydropyrimidinones. ▶ Biginelli reaction in the presence of Yb(PFO)3 under solvent-free conditions. ▶ Ethyl 4,4-difluoroacetoacetate used as substrate. ▶ Comparison of reaction conditions and products was made among three 1,3-dicarbonyl substrates.