Copper(II) acetate mediated conversion of ortho aminomethyl substituted isoquinolines to bis(isoquinolylcarbonyl)amides

► Ortho aminomethyl substituted isoquinolines readily convert to respective bis(isoquinolylcarbonyl)amide. ► Reaction in air with [Cu(OAc)2(H2O)]2 in ethanol achieve this conversion. ► Oxidation of methylene group and N-C bond coupling are important steps.