کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10578531 979750 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and cytotoxicity of new Pt(IV) complexes of 2,2′-biimidazole and derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Synthesis and cytotoxicity of new Pt(IV) complexes of 2,2′-biimidazole and derivatives
چکیده انگلیسی
Compounds of type [PtCl4(LL)] [LL = 2,2′-biimidazole (H2bim), N-methyl-2,2′-biimidazole (MeHbim), N-hydroxyethyl-2,2′-biimidazole (HOEtHbim), or N,N′-dimethyl-2,2′-biimidazole (Me2bim)] were prepared and characterized. The structure of [PtCl4(Me2bim)] was determined by X-ray diffractometry. The new compounds were tested for cytotoxicity against the human ovarian cancer cell line A2780 and the cisplatin-resistant line A2780cis. All of them, except the HOEtHbim derivative, circumvent cisplatin-induced resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polyhedron - Volume 24, Issue 10, 14 July 2005, Pages 1196-1202
نویسندگان
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