Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity

Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 5, 1 March 2015, Pages 1140-1145

Pierre L. Beaulieu, Gordon Bolger, Dan Deon, Martin Duplessis, Gulrez Fazal, Alexandre Gagnon, Michel Garneau, Steven LaPlante, Timothy Stammers, George Kukolj, Jianmin Duan,