کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10587303 | 981426 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 μM. This compound accounted for â¼95% of P. falciparum growth inhibitory activity in the crude extract confirming, for this TCM, that a single compound was responsible for the antimalarial activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 21, 1 November 2013, Pages 5915-5918
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 21, 1 November 2013, Pages 5915-5918
نویسندگان
Hongmin Wang, Weimin Zhao, Vanida Choomuenwai, Katherine T. Andrews, Ronald J. Quinn, Yunjiang Feng,