کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10587314 981426 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Benzohydroxamic acids as potent and selective anti-HCV agents
ترجمه فارسی عنوان
اسانس بنزو هیدروکسام به عنوان داروی ضد ویروسی قوی و انتخابی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations. The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 21, 1 November 2013, Pages 5936-5940
نویسندگان
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