کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10587347 981426 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor
ترجمه فارسی عنوان
اسید 4-فنیل بوتیریک در برابر مرگ سلول های عصبی محافظت می کند و عمدتا به عنوان یک مهار کننده شیمیایی به جای مهارکننده هیستون دیاستیلاز
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
This letter describes the mechanism behind the protective effect of 4-phenylbutyric acid (4-PBA) against endoplasmic reticulum (ER) stress-induced neuronal cell death using three simple 4-(p-substituted phenyl) butyric acids (4-PBA derivatives). Their relative human histone deacetylase (HDAC) inhibitory activities were consistent with a structural model of their binding to HDAC7, and their ability to suppress neuronal cell death and activity of chemical chaperone in vitro. These data suggest that 4-PBA protects against neuronal cell death mediated by the chemical chaperone activity rather than by inhibition of histone deacetylase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 21, 1 November 2013, Pages 6015-6018
نویسندگان
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