کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10587603 981431 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators
چکیده انگلیسی
Following the recent identification of the naturally occurring 3-ylidene-4,5-dihydrophthalide ligustilide and its oxidation product dehydroligustilide as novel TRPA1 modulators, a series of seventeen 3-ylidenephthalides was synthesized and tested on TRPA1 and TRPM8 channels. Most of these compounds acted as strong modulators of the two channel types with EC50 and/or IC50 values distinctly lower than those of the reference compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 20, 15 October 2013, Pages 5614-5618
نویسندگان
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